Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating

Summary, in English

Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.

• Author: Andreas Edsfeldt; Kristina Eriksson Stenström; Jiangming Sun; Nuno Dias; Göran Skog; Pratibha Singh; Sören Mattsson; Jan Nilsson; Isabel Gonçalves
• Department/s: Cardiovascular Research - Translational Studies; EXODIAB: Excellence of Diabetes Research in Sweden; Nuclear physics; Vascular Diseases - Clinical Research; Quaternary Sciences; Medical Radiation Physics, Malmö; Cardiovascular Research - Immunity and Atherosclerosis; EpiHealth: Epidemiology for Health
• Publishing year: 2021
• Language: English
• Pages: 734-745
• Publication/Series: JACC: Basic to Translational Science
• Volume: 6
• Issue: 9-10
• Links: http://dx.doi.org/10.1016/j.jacbts.2021.08.005
• Document type: Journal article
• Publisher: Elsevier
• Topic: Cardiac and Cardiovascular Systems
• Status: Published
• Research group: Cardiovascular Research - Translational Studies; Vascular Diseases - Clinical Research; Medical Radiation Physics, Malmö; Cardiovascular Research - Immunity and Atherosclerosis
• ISBN/ISSN/Other: ISSN: 2452-302X