The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

LU

Emma Hammarlund

Research team manager

LU

It doesn’t always pay to be fit : success landscapes

Author

  • Trung V. Phan
  • Gao Wang
  • Tuan K. Do
  • Ioannis G. Kevrekidis
  • Sarah Amend
  • Emma Hammarlund
  • Ken Pienta
  • Joel Brown
  • Liyu Liu
  • Robert H. Austin

Summary, in English

Landscapes play an important role in many areas of biology, in which biological lives are deeply entangled. Here we discuss a form of landscape in evolutionary biology which takes into account (1) initial growth rates, (2) mutation rates, (3) resource consumption by organisms, and (4) cyclic changes in the resources with time. The long-term equilibrium number of surviving organisms as a function of these four parameters forms what we call a success landscape, a landscape we would claim is qualitatively different from fitness landscapes which commonly do not include mutations or resource consumption/changes in mapping genomes to the final number of survivors. Although our analysis is purely theoretical, we believe the results have possibly strong connections to how we might treat diseases such as cancer in the future with a deeper understanding of the interplay between resource degradation, mutation, and uncontrolled cell growth.

Department/s

  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • EpiHealth: Epidemiology for Health
  • Molecular Evolution
  • LUCC: Lund University Cancer Centre
  • Division of Translational Cancer Research

Publishing year

2021

Language

English

Pages

387-400

Publication/Series

Journal of Biological Physics

Volume

47

Issue

4

Document type

Journal article

Publisher

Springer

Topic

  • Ecology

Keywords

  • Cancer
  • Evolution dynamics
  • Extinction
  • Fitness
  • Landscapes
  • Mutations
  • Resources

Status

Published

Research group

  • Molecular Evolution

ISBN/ISSN/Other

  • ISSN: 0092-0606