Emma Hammarlund
Research team manager
It doesn’t always pay to be fit : success landscapes
Author
Summary, in English
Landscapes play an important role in many areas of biology, in which biological lives are deeply entangled. Here we discuss a form of landscape in evolutionary biology which takes into account (1) initial growth rates, (2) mutation rates, (3) resource consumption by organisms, and (4) cyclic changes in the resources with time. The long-term equilibrium number of surviving organisms as a function of these four parameters forms what we call a success landscape, a landscape we would claim is qualitatively different from fitness landscapes which commonly do not include mutations or resource consumption/changes in mapping genomes to the final number of survivors. Although our analysis is purely theoretical, we believe the results have possibly strong connections to how we might treat diseases such as cancer in the future with a deeper understanding of the interplay between resource degradation, mutation, and uncontrolled cell growth.
Department/s
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- EpiHealth: Epidemiology for Health
- Molecular Evolution
- LUCC: Lund University Cancer Centre
- Division of Translational Cancer Research
Publishing year
2021
Language
English
Pages
387-400
Publication/Series
Journal of Biological Physics
Volume
47
Issue
4
Document type
Journal article
Publisher
Springer
Topic
- Ecology
Keywords
- Cancer
- Evolution dynamics
- Extinction
- Fitness
- Landscapes
- Mutations
- Resources
Status
Published
Research group
- Molecular Evolution
ISBN/ISSN/Other
- ISSN: 0092-0606