Emma Hammarlund
Research team manager
I wonder why it took so long for large lifeforms to evolve on Earth, and I focus on the chemical and biological changes that led up to the Cambrian explosion of animal diversity. To explore these changes, I utilize both geochemistry that reflects ocean chemistry at the Precambrian/Cambrian boundary, and experimental biology to decipher the prerequisites of tissue formation. The formation and evolution of tissue can be studied, in fast-track, via tumors. Tumors repeatedly demonstrate a capacity to jump from unicellularity to multicellularity, and they use cellular abilities that were acquired during evolution. These abilities are likely to still remain important for tissue maintenance, whether or not the tissue is malignant or normal. An evolutionary view on the interactions within tissue and between tissue and the environment is, therefore, an important step when getting at the history of life.
Current projects revolve around oxygen sensing mechanisms and Paleozoic water column chemistry. The research is possible thanks for funding from the Swedish Research Council, the Crafoord Foundation, the Royal Physiographic Society, the Gyllenstiernska Krapperup Foundation, and Magnus Bergvall Foundations. The research is also possible thanks to post-doc Hwei-yen Shen and to other excellent collaborators.
Publications
Displaying of publications. Sorted by year, then title.
AlphaML : A clear, legible, explainable, transparent, and elucidative binary classification platform for tabular data
Ahmad Nasimian, Saleena Younus, Özge Tatli, Emma U. Hammarlund, Kenneth J. Pienta, et al.
(2024) Patterns, 5
Journal articleA mathematical investigation of polyaneuploid cancer cell memory and cross-resistance in state-structured cancer populations
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, et al.
(2023) Scientific Reports, 13
Journal article“Hypoxic” Silurian oceans suggest early animals thrived in a low-O2 world
Emma R. Haxen, Niels H. Schovsbo, Arne T. Nielsen, Sylvain Richoz, David K. Loydell, et al.
(2023) Earth and Planetary Science Letters, 622
Journal articleThe contribution of evolvability to the eco-evolutionary dynamics of competing species
Anuraag Bukkuri, Kenneth J. Pienta, Sarah R. Amend, Robert H. Austin, Emma U. Hammarlund, et al.
(2023) Ecology and Evolution, 13
Journal articleModeling cancer’s ecological and evolutionary dynamics
Anuraag Bukkuri, Kenneth J. Pienta, Ian Hockett, Robert H. Austin, Emma U. Hammarlund, et al.
(2023) Medical Oncology, 40
Journal articleRoadmap to the study of gene and protein phylogeny and evolution—A practical guide
Florian Jacques, Paulina Bolivar, Kristian Pietras, Emma U. Hammarlund
(2023) PLoS ONE, 18
Journal articleDistinct Cholesterol Localization in Glioblastoma Multiforme Revealed by Mass Spectrometry Imaging
Mai H. Philipsen, Ellinor Hansson, Auraya Manaprasertsak, Stefan Lange, Eva Jennische, et al.
(2023) ACS Chemical Neuroscience, 14 p.1602-1609
Journal articleUpdating the Definition of Cancer
Joel S. Brown, Sarah R. Amend, Robert H. Austin, Robert A. Gatenby, Emma U. Hammarlund, et al.
(2023) Molecular cancer research : MCR, 21 p.1142-1147
Journal articleRapid marine oxygen variability : Driver of the Late Ordovician mass extinction
Nevin P. Kozik, Seth A. Young, Sean M. Newby, Mu Liu, Daizhao Chen, et al.
(2022) Science Advances, 8
Journal articleCancer cells employ an evolutionarily conserved polyploidization program to resist therapy
K. J. Pienta, E. U. Hammarlund, R. H. Austin, R. Axelrod, J. S. Brown, et al.
(2022) Seminars in Cancer Biology, 81 p.145-159
Journal articleOrigin and evolution of animal multicellularity in the light of phylogenomics and cancer genetics
Florian Jacques, Etienne Baratchart, Kenneth J. Pienta, Emma U. Hammarlund
(2022) Medical Oncology, 39
Journal articleStochastic models of Mendelian and reverse transcriptional inheritance in state-structured cancer populations
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, et al.
(2022) Scientific Reports, 12
Journal articleA life history model of the ecological and evolutionary dynamics of polyaneuploid cancer cells
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, et al.
(2022) Scientific Reports, 12
Journal articleMapping the chemistry of hair strands by mass spectrometry imaging-a review
Mai H. Philipsen, Emma R. Haxen, Auraya Manaprasertsak, Per Malmberg, Emma U. Hammarlund
(2021) Molecules, 26
Journal articleRedox dynamics of later Cambrian oceans
Benjamin C. Gill, Tais W. Dahl, Emma U. Hammarlund, Matthew A. LeRoy, Gwyneth W. Gordon, et al.
(2021) Palaeogeography, Palaeoclimatology, Palaeoecology, 581
Journal articleThe Sedimentary Geochemistry and Paleoenvironments Project
Úna C. Farrell, Emma Hammarlund, Sylvain Richoz, Erik A. Sperling
(2021) Geobiology, 19 p.545-556
Journal articleSulfidic anoxia in the oceans during the Late Ordovician mass extinctions – insights from molybdenum and uranium isotopic global redox proxies
Tais W. Dahl, Emma U. Hammarlund, Christian Mac Ørum Rasmussen, David P.G. Bond, Donald E. Canfield
(2021) Earth-Science Reviews, 220
Journal article reviewHypoxia Generated by Avian Embryo Growth Induces the HIF-α Response and Critical Vascularization
Christopher Carroll, Niklas Engström, Patrik F. Nilsson, Emma R. Haxen, Sofie Mohlin, et al.
(2021) Frontiers in Ecology and Evolution, 9 p.1-15
Journal articleCancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells
K. J. Pienta, E. U. Hammarlund, J. S. Brown, S. R. Amend, R. M. Axelrod
(2021) Proceedings of the National Academy of Sciences of the United States of America, 118
Journal articleIt doesn’t always pay to be fit : success landscapes
Trung V. Phan, Gao Wang, Tuan K. Do, Ioannis G. Kevrekidis, Sarah Amend, et al.
(2021) Journal of Biological Physics, 47 p.387-400
Journal articleHypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells
Camilla U. Niklasson, Elina Fredlund, Emanuela Monni, Jessica M. Lindvall, Zaal Kokaia, et al.
(2021) Developmental Dynamics, 250 p.191-236
Journal articleDevelopment of Iron Speciation Reference Materials for Palaeoredox Analysis
Lewis J. Alcott, Alexander J. Krause, Emma U. Hammarlund, Christian J. Bjerrum, Florian Scholz, et al.
(2020) Geostandards and Geoanalytical Research, 44 p.581-591
Journal articleConvergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer
Kenneth J Pienta, Emma U Hammarlund, Robert Axelrod, Sarah R Amend, Joel S Brown
(2020) Molecular cancer research : MCR, 18 p.801-810
Journal article reviewHarnessing hypoxia as an evolutionary driver of complex multicellularity : Hypoxia drives multicellular evolution
Emma U. Hammarlund
(2020) Interface Focus, 10
Journal articlePoly-aneuploid cancer cells promote evolvability, generating lethal cancer
Kenneth J. Pienta, Emma U. Hammarlund, Robert Axelrod, Joel S. Brown, Sarah R. Amend
(2020) Evolutionary Applications, 13 p.1626-1634
Journal articleOxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity
Emma U. Hammarlund, Emily Flashman, Sofie Mohlin, Francesco Licausi
(2020) Science (New York, N.Y.), 370
Journal article reviewThe issues with tissues : the wide range of cell fate separation enables the evolution of multicellularity and cancer
Emma U. Hammarlund, Sarah R. Amend, Kenneth J. Pienta
(2020) Medical Oncology, 37
Journal articleThe sirius passet lagerstätte of north greenland : A remote window on the cambrian explosion
David A.T. Harper, Emma U. Hammarlund, Timothy P. Topper, Arne T. Nielsen, Jan A. Rasmussen, et al.
(2019) Journal of the Geological Society, 176 p.1023-1037
Journal article reviewPaleoenvironmental proxies and what the Xiamaling Formation tells us about the mid-Proterozoic ocean
Shuichang Zhang, Xiaomei Wang, Huajian Wang, Christian J. Bjerrum, Emma U. Hammarlund, et al.
(2019) Geobiology, 17 p.225-246
Journal articleThe Sirius Passet Lagerstätte of North Greenland—A geochemical window on early Cambrian low-oxygen environments and ecosystems
Emma U. Hammarlund, M. Paul Smith, Jan A. Rasmussen, Arne T. Nielsen, Donald E. Canfield, et al.
(2019) Geobiology, 17 p.12-26
Journal articleEarly Silurian δ 13 C org excursions in the foreland basin of Baltica, both familiar and surprising
Emma U. Hammarlund, David K. Loydell, Arne T. Nielsen, Niels H. Schovsbo
(2019) Palaeogeography, Palaeoclimatology, Palaeoecology, 526 p.126-135
Journal articleThe aerobic diagenesis of Mesoproterozoic organic matter
Xiaomei Wang, Wenzhi Zhao, Shuichang Zhang, Huajian Wang, Jin Su, et al.
(2018) Scientific Reports, 8 p.1-10
Journal articleValuable snapshots of deep time
Emma U. Hammarlund
(2018) Nature Geoscience, 11 p.298-299
Journal article (comment)A Mesoproterozoic iron formation
Donald E. Canfield, Shuichang Zhang, Huajian Wang, Xiaomei Wang, Wenzhi Zhao, et al.
(2018) Proceedings of the National Academy of Sciences of the United States of America, 115 p.3895-3904
Journal articleRefined control of cell stemness allowed animal evolution in the oxic realm
Emma U. Hammarlund, Kristoffer Von Stedingk, Sven Påhlman
(2018) Nature Ecology and Evolution, 2 p.220-228
Journal article reviewEarly Cambrian oxygen minimum zone-like conditions at Chengjiang
Emma U. Hammarlund, Robert R. Gaines, Maria G. Prokopenko, Changshi Qi, Xian Guang Hou, et al.
(2017) Earth and Planetary Science Letters, 475 p.160-168
Journal articleOxygen, climate and the chemical evolution of a 1400 million year old tropical marine setting
Xiaomei Wang, Shuichang Zhang, Huajian Wang, Christian J. Bjerrum, Emma U. Hammarlund, et al.
(2017) American Journal of Science, 317 p.861-900
Journal articleThe oxic degradation of sedimentary organic matter 1400 Ma constrains atmospheric oxygen levels
Shuichang Zhang, Xiaomei Wang, Huajian Wang, Emma U. Hammarlund, Jin Su, et al.
(2017) Biogeosciences, 14 p.2133-2149
Journal articleDisentangling the record of diagenesis, local redox conditions, and global seawater chemistry during the latest Ordovician glaciation
Anne Sofie C Ahm, Christian J Bjerrum, Emma U. Hammarlund
(2017) Earth and Planetary Science Letters, 459 p.145-156
Journal articleRemarkable preservation of microfossils and biofilms in mesoproterozoic silicified bitumen concretions from Northern China
Xiaomei Wang, Shuichang Zhang, Huajian Wang, Donald E. Canfield, Jin Su, et al.
(2017) Geofluids, 2017
Journal articleReply to Planavsky et al. : Strong evidence for high atmospheric oxygen levels 1,400 million years ago
Shuichang Zhang, Xiaomei Wang, Huajian Wang, Christian J Bjerrum, Emma U Hammarlund, et al.
(2016) Proceedings of the National Academy of Sciences of the United States of America, 113 p.3-2552
Journal article (letter)Sufficient oxygen for animal respiration 1,400 million years ago
Shuichang Zhang, Xiaomei Wang, Huajian Wang, Christian J Bjerrum, Emma U Hammarlund, et al.
(2016) Proceedings of the National Academy of Sciences of the United States of America, 113 p.6-1731
Journal articleOrbital forcing of climate 1.4 billion years ago
Shuichang Zhang, Xiaomei Wang, Emma U Hammarlund, Huajian Wang, M Mafalda Costa, et al.
(2015) Proceedings of the National Academy of Sciences of the United States of America, 112 p.13-1406
Journal articleThe 2.1 Ga old Francevillian biota : Biogenicity, taphonomy and biodiversity
Abderrazak El Albani, Stefan Bengtson, Donald E Canfield, Armelle Riboulleau, Claire Rollion Bard, et al.
(2014) PLoS ONE, 9
Journal articleEnd Ordovician extinctions : A coincidence of causes
David A T Harper, Emma U. Hammarlund, Christian M Ø Rasmussen
(2014) Gondwana Research, 25 p.1294-1307
Journal article reviewTracing euxinia by molybdenum concentrations in sediments using handheld X-ray fluorescence spectroscopy (HHXRF)
Tais W Dahl, Micha Ruhl, Emma U. Hammarlund, Donald E Canfield, Minik T. Rosing, et al.
(2013) Chemical Geology, 360-361 p.241-251
Journal articleOxygen dynamics in the aftermath of the Great Oxidation of Earth's atmosphere
Donald E Canfield, Lauriss Ngombi-Pemba, Emma U Hammarlund, Stefan Bengtson, Marc Chaussidon, et al.
(2013) Proceedings of the National Academy of Sciences of the United States of America, 110 p.41-16736
Journal articlePaleoredox and pyritization of soft-bodied fossils in the ordovician frankfort shale of New York
Una C. Farrell, Derek E G Briggs, Emma U. Hammarlund, Erik A. Sperling, Robert R. Gaines
(2013) American Journal of Science, 313 p.452-489
Journal articleReply to Butterfield : Low-sulfate and early cements inhibit decay and promote Burgess Shale-type preservation
Robert R. Gaines, Emma U. Hammarlund, Xianguang Hou, Changshi Qi, Sarah E Gabbott, et al.
(2012) Proceedings of the National Academy of Sciences of the United States of America, 109
Journal article (letter)A sulfidic driver for the end-Ordovician mass extinction
Emma U. Hammarlund, Tais W Dahl, David A T Harper, David P G Bond, Arne T. Nielsen, et al.
(2012) Earth and Planetary Science Letters, 331-332 p.128-139
Journal articleMechanism for Burgess Shale-type preservation
Robert R. Gaines, Emma U Hammarlund, Xianguang Hou, Changshi Qi, Sarah E Gabbott, et al.
(2012) Proceedings of the National Academy of Sciences of the United States of America, 109 p.4-5180
Journal articleBurgess shale-type biotas were not entirely burrowed away
Robert R. Gaines, Mary L. Droser, Patrick J. Orr, Daniel Garson, Emma Hammarlund, et al.
(2012) Geology, 40 p.283-286
Journal articleDo large predatory fish track ocean oxygenation?
Tais W Dahl, Emma U Hammarlund
(2011) Communicative and Integrative Biology, 4 p.4-92
Journal articleThe influence of sulfate concentration on soft-tissue decay and preservation
Emma Hammarlund, Don E. Canfield, Stefan Bengtson, Peter Mygind Leth, Burkhard Schillinger, et al.
(2011) Palaeontographica Canadiana , p.141-156
Journal articleDevonian rise in atmospheric oxygen correlated to the radiations of terrestrial plants and large predatory fish
Tais W Dahl, Emma U Hammarlund, Ariel D. Anbar, David P G Bond, Benjamin C Gill, et al.
(2010) Proceedings of the National Academy of Sciences of the United States of America, 107 p.5-17911
Journal articleLarge colonial organisms with coordinated growth in oxygenated environments 2.1 Gyr ago
Abderrazak El Albani, Stefan Bengtson, Donald E Canfield, Andrey Bekker, Roberto Macchiarelli, et al.
(2010) Nature, 466 p.4-100
Journal article (letter)Neutron tomography for understanding the evolution of life
E. Hammarlund, Burkhard Schillinger, Elbio Calzada
(2008) 8th World Conference on Neutron Radiography, WCNR-8 , p.448-451
Conference paper