Emma Hammarlund
Research team manager
Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity
Author
Summary, in English
Oxygen-sensing mechanisms of eukaryotic multicellular organisms coordinate hypoxic cellular responses in a spatiotemporal manner. Although this capacity partly allows animals and plants to acutely adapt to oxygen deprivation, its functional and historical roots in hypoxia emphasize a broader evolutionary role. For multicellular life-forms that persist in settings with variable oxygen concentrations, the capacity to perceive and modulate responses in and between cells is pivotal. Animals and higher plants represent the most complex life-forms that ever diversified on Earth, and their oxygen-sensing mechanisms demonstrate convergent evolution from a functional perspective. Exploring oxygen-sensing mechanisms across eukaryotic kingdoms can inform us on biological innovations to harness ever-changing oxygen availability at the dawn of complex life and its utilization for their organismal development.
Department/s
- LUCC: Lund University Cancer Centre
- Lithosphere and Biosphere Science
- Division of Translational Cancer Research
- Childhood Cancer Research Unit
Publishing year
2020
Language
English
Publication/Series
Science (New York, N.Y.)
Volume
370
Issue
6515
Document type
Journal article review
Publisher
American Association for the Advancement of Science (AAAS)
Topic
- Biochemistry and Molecular Biology
Status
Published
Research group
- Childhood Cancer Research Unit
ISBN/ISSN/Other
- ISSN: 1095-9203